Often, spattering is a sign that the paint is not thinned sufficiently.
If the spattering is only occurring when you first start the air/paint flow and then becomes "normal", it's more likely an accumulation of paint on the tip of the needle, which gets blasted away (towards your model) when you press the button.
You can wipe, as suggested above and you can also get into the habit of starting the airflow with your airbrush ponted away from the model. Start the air and then bring your airbrush to bear on the areas to be painted. This works for most tasks, with the exception of spots/mottling.