Resin dust is fine and inert. It is not carcinogenic or toxic in any other way. If dust, sawdust, household dust, etc,, bothers you, a dust mast is really all you need. In fact, given the make up of house dust, is more likely to be an allergen. There's a small possibility of allergic reaction for some small number of people. However, being fine it is messy. I use a razor saw for large blocks and either wire cutters or a #1 blade. Simple fine sand paper will clean up any left over lines.
Given you're using parts for a cockpit, I'd avoid the torque of a Dremel and use hand powered tools to cut off the pour plugs.
Some parts and some resins can be very brittle so use caution when cutting thin pieces.
You'll need to use some form of super glue, i.e., Zap-A-Gap, to assemble and attach these parts to your kit.
As far as painting, use high quality brushes and good paint products. If you're buying brushes by the dozen, you're wasting your money. Make sure your paint is formulated to be brush friendly. Know that Tamiya paint is not (and hasn't been for 25 years) brush friendly.