A fair amount of experience on that. Aircraft or ships?
For ships, a first question is scale. I don't use mono for anything bigger that 1/350.
And the clear nylon stuff is hard to work with. But there are good gray or black lines available that are easy to tie, and most don't dissolve from CA.
Look for fly tying line, like Uni Caenis. It's my favorite.
Another option is EZ Line. It's elastic so it self tightens. Some drawbacks- its not round but kind of flat. And CA seems to make it shrivel. but it knots easily.