I made the switch to acrylic (actually the old PolyS brand, which, as I understand it, was technically latex) about 25 years ago. I still use enamels for metallics and various other specific applications, but I'm a confirmed acrylic enthusiast.
Maybe I should emphasize that I'm primarily a ship modeler and brush by hand about 90 percent of the time. I've got an airbrush, but I don't use it often.
I was working in a hobby shop when the PolyS brand appeared, and initially I didn't think much of it. I'd been using enamels and, occasionally, laquers for about 20 years (my memory goes back to paint brands like Aurora, Revell, and Ulrich), and the water-based stuff just didn't seem to handle right. But when I took the trouble to practice a little with it and develop a slightly different brush technique, I came to the conclusion that this new stuff was great. Once I got a little practice with it, it left virtually no brushmarks, it was easy to clean up mistakes, it dried fast, and techniques like washes and dry-brushing worked superbly with it. The clincher came, though, when I realized that I was spending five or six hours at a stretch in the workshop, where I'd previously been getting tired after three or four. The fumes from the enamel and thinner had been giving me mild headaches without my knowing it.
My current favorite brand is PolyScale, which is a variant on the old PolyS. (I actually liked the consistency of the old stuff a little better, but the new brand works fine.) The nearest hobby shop that carries PolyScale is about 35 miles away; the local Hungate's chain store sells Testor's Acryl, so if I get in a jam and need a particular color in a hurry I use that. But I don't care fas much or the texture of Testor's. It's got a tendency to act like syrup, and occasionally dries with a slightly glossy sheen.
My biggest complaint about PolyScale is that in some applications it dries too fast for my taste. I've read suggestions about slowing it down with various artist acrylic mediums; one of these days I'll try that.
I urge anybody who's never done so to give acrylics a try. They handle a little differently than enamels, and take a little practice. But the results can be excellent.