Hi, Thyamis!
I've only built two vac kits my whole life: a huge Graf Zeppelin distributed by Testors, and Lunar Models' Martian War Machine (G. Pal version).
The Graf Zep was done in very thin, flexible plastic, so there was no sanding possible after I cut the halves out of the sheet. Just had to make the cuts as straight and accurate as possible the first time out. I had to butress all along the edges to join those big, floppy halves. I remember as a teenager thinking modeling couldn't get any more difficult than that! Finally, I got it all together.
The Martian War Machine was easier only in that it was formed in a thick plastic and could be sanded easily after the top and bottom halves were cut out of the sheet. Once the halves were joined and the remaining seams puttied and sanded, it looked exactly like the smooth, seamless machines as seen in the film.
From the experience gained building those two kits, I wouldn't shy away from a vac kit now at all.
Actually, I've always wanted to tackle that huge 1/72 C-5...