There are two ways to proceed here.
1. You already have a base so you design your scene to fit the base.
2. You have models but no base. here you design a scene that makes sense and clearly, I repeat, CLEARLY, tells a story and you get a base to fit by having placed your elements around beforehand.
A good thing to do in either case is to lay out variations of your scene and take digital photos of it to see which works best and gets your point across. By posting those in progress or planning shots here or on other sites, you may get some good feedback. Ignore those that tell you to do what you want, they're your models/it's your diorama. That's one of my pet peeves and it's as useless at, well, you-know-whats on a bull.