Other than cost, the main disadvantage of the V-22 versus a helo is that the Osprey cannot autorotate in an emergency. The swept area of the rotors is less than that of a helicopter, and so it would come down pretty hard.
But the tiltrotor concept is a game changer and is therefore justified IMHO. Regarding the cargo cabin size, I’m sure a “fat” Osprey or similar craft can be developed in the near future. Also have to keep in mind the Osprey is the world’s first operational tiltrotor, so there will be bugs to wring out.