some type of separator is not a bad Idea. the mold needs to be dead smooth so I would consider making sure it is like glass, ANY imperfections will show in the final product. the mold needs to be dry as a bone. {moisture will bubble up between the mold and material}
A totally dry mold that has some vasoline applied, then heated so it is THAT thin of a coat. We use a spray but it is not available in the general market.
You could do a thin film of 20 minute casting plaster that can be polished to that level of smoothness, then if dry it may well vac fine.
If it is a very detailed mold a parting agent is needed {under cuts etc}
Dan {30 years vacuforming parts for artifical legs and braces}