Depends on whether you use brass or plastic tubing. In either case, a jig of some sort helps, but the jig is all important if you use brass and plan on soldering. You need a good jig that can hold all the joints you have already soldered in place while you do the others.
I often do it like the old balsa and tissue airplane models. I make up the sides, then put them in another jig while I add the cross members. I find making two jigs, one for the sides and one for the assembly of the crossmembers, easier than one complex 3D jig that holds everything together.
I used to use brass a lot, but have found using plastic tubing and CA a lot easier than brass and solder- cheaper, too. Also, for stiffer frames I often now use plastic rod rather than tubing (plus, for smaller scales it is harder to find small diameter plastic tubing). Also, for areas that you have to bend the tubing, rod bends easier than tubing.