I use Mr. Surfacer too. Good stuff. (As a side note, I've had good results thinning it even further with lacquer thinner) and using it as a primer).
I use automotive spot/glaze putty too, and it can be thinned with a little lacquer thinner, or even some nail polish remover (acetone). Lots of people apply the putty, wait for it to dry, and then 'smooth' the joint over with a q-tip dipped in nail polish remover. Great technique and a nice way to remove any excess putty that got a little out-of-control, without worrying about sanding off important details in the plastic.
I wouldn't use any of these types of putties for 'large' fill areas. As mentioned, I've heard that they tend to soften the plastic if used in thick applications. Several thin layers would be better. Or, better yet, use an epoxy putty (like Milliput) instead.
I've also used CA to fill areas successfully. CA is starting to become my filler of choice. I hate waiting for putty to dry, and with CA, I can cure it instantly with some accelerator. I've been using CA to fill panel lines and wing-root joints too. Works really well for me. The trick is to sand it right away (after the accelerator). If you wait to long, it becomes rock hard and get's to be a real bugger to sand without wrecking the surrounding plastic.
Hope something in there will help
Murray