Some folks will say it depends on whether you are using acrylics or enamels, and what brand as well. Tamiya's acrylics have excellent adhesion, even without primer for example.
I came back to scale modeling after years of painting gaming miniatures and vehicles for games like Warhammer 40k. As such, I painted a ton of mixed media. Pewter, resin, and various grades of plastic, as well as epoxy putties used to sculpt or improve detail.
Short answer, I prime EVERYTHING I paint! Even a light coat of duplicolor sandable automotive primer gives your airbrushed paints (and any hand brushed details) a good surface to 'bite' into. It sprays very fine (designed for auto body work), comes in multiple colors, and is sandable!
Give it a try, you won't be disappointed!
Chris
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