Generally, they are ready for brush painting right out of the bottle. They work very nicely with a brush.
They thin fine with plain water for brush painting. (For airbrushing I use their proprietary thinner or my tip clogs up too quickly)
Always use a pallet, old bottle cap, pill tray, or whatever to thin and mix paints. Never add anything to the paint bottle itself. You may contaminate your paint with something it doesn't agree with and ruin the whole bottle.