For years I ended up wrecking good brushes, using all different paints. Acrylics seemed the worst, if not cleaned well every few minutes they got totally gummed up, with the set up paint clogging the rear portion of the bristles. Lacquer thinner did a fair job of reducing the build up, but still the stuff would break up into tiny dusty like particles, transferring into the finish being brushed on.
I don't recall why, but for some reason I tried acetone and a several minute soak in a shallow metal bowl, with the entire bristle end submerged. After making brush strokes around in the bowl, the build up began breaking up into those tiny particles and settling at the bottom. Drying the brush and repeating the process with clean acetone, soon enough the brush was clean as new and in fully restored condition, or remarkably close to it..
To the best of my knowledge, the acetone has no damaging effect on the quality of the brush material, (I think most of mine are sable.) I rarely do any brushing, except for very small components, but so far this method is working quite well for me. After cleaning I use a very small dab of mineral oil on the bristles, brush strokes working it in, then a wipe down after to keep the bristles from getting stiff, Must remember to clean that out with a compatible thinner and clean kitchen towel, before painting. I do try to keep the brushes dedicated to certain paint types, not going from type to type with the same brush.
Hope it works for you. Best
Patrick