When I began airbrushing about 50 years ago, I used model enamel paint. Clueless about the nature of paint fumes and the hazards associated, no mask, no open window, NO venting of fumes directed away from me. By the second session I was in serious medical distress, the Doctor told me that the raw fumes had really affected my respiratory system, the coughing and wheezing lasted for a few days.
I suppose it can be said that the fumes could bother some more than others, but I could also point out that exposure surely can't be considered good for anyone. Painting outside with a light breeze displacing the fumes away likely would be OK, or even indoors with sufficient removal of fumes by suitable venting means. Otherwise, an adequate respirator should be considered required.
I use a spray booth with very positive flow through a filter, then fumes are vented via duct to outside exit port, which is sealed around the duct. Even with that system, still I use a mask when painting, and especially when cleaning up the equipment when painting is finished. Since I have been at this hobby for so long and I do a lot of painting, I do consider it essential to maximize health protection. As Jon rightly pointed out you're only issued one set of lungs, use 'em, don't abuse 'em.
I made my own booth, the design features of many others were incorporated, the final product is my fourth effort, it works quite well and is convenient. Total cost of this one, perhaps $75. The same as you need good light for painting, your lungs need clean air. I wish good health for all, and recommend doing whatever needed to preserve your respiratory function. The skin is alleged to be the most absorptive part of the anatomy, so appropriate glove protection should be considered as well.
But even I don't use a bio hazard suit, (yet I do like the looks of the bright yellow ones.)
Patrick