I use the IWATA TRN1 Trigger style airbrush and i can use three or even four colors at a single sitting. Here is my routine for cleaning between color changes
1. Dump excess paint from the cup
2. Use either IPA or manufactuers thinner in the cup and use a cotton bud to clean out the cup and the port under the cup while i am running the thinner through the gun
3. Repeat step three at least 2 more times.
4. When the IPA or thinner comes out clear you can then change to a different color
Good luck and i hope that this helps