I'm with Scott. If I'm applying extra coats, I wait anywhere from 15 minutes to a couple of hours. If it's a laquer, it'll probably 'flash' pretty quick and extra coats can go on quicker.
For 'handling', I usually wait at least a few days. My impatience sometimes get's the best of me, and when that happens, I often end up with a fingerprint or a dent of some sort in the paint. If you're doing any polishing, definitely wait until the paint is fully cured. Scott's 'smell-test' is what I use, and it's the best one I've found yet. Note that some colors seem to take longer than others to cure. Silver seems to take a really long time... (I had one that took 3 weeks before I couldn't smell it anymore...)
Murray