I use Badger brushes, so I may be off base here, but I think the 0.2 and 0.3mm nozzles / needles are for inks or very, very thin paints. Saltydog can provide more information since he's the Iwata freak around here, but I think I remember him saying that he uses a 0.5mm combination (or maybe it was 0.35mm).
Internal mix, double-action, gravity feed with solvent-resistant O-rings are definitely the way to go though.