Ray,
I don't know for sure what the difference is in the make up of the paints but the sealer type primers go on as a smoother harder layer. The sandable primers are fluffier(for lack of a better word) and fill in small scratches and such better, especially the *high build up* type. Sandables are more porous by nature and chalky.
Not all automotive primers are sealers. I had forgotten about the different types of primers till recently myself. In thinking back I can remember articles in auto mags talking about the different types. Mainly for do-it-yourselfers that may be getting a vehicle ready for paint and having to do the bodywork a little at a time. If you've ever seen a car or truck running around with rust bleeding through the primer, they didn't use a sealing type. It let moisture bleed through to the bare metal and start the rusting process all over again.(or maybe they didn' t get rid of all the rust to begin with
, either way, it bled through)
It works both ways too. Not only does a sealer keep colored plastic from bleeding through the paint, it won't soak up as much paint or be affected as much by the solvents in the paint so you could get away with a *hotter* paint without crazing the plastic.
I've been using DupliColor primers in a spray can and have had good luck. Over the last couple weeks I've started using a sealing primer once I've got the bodywork done and it has made a difference in coverage with the color coats. I have an older Monogram kit molded in red that I've been working my way up to. That plastic seems really soft and the few parts I used Testors glue on, it melted the heck out of so I'm anxious(and skeered) to see how the primer affects it. Always try something new on scrap of course...
Not a definitive answer but like Murphy's Law states; if you're not certain of the answer, at least make it sound convincing...