Oh my, this is Chevy vs. Ford! The dyed in the wool enamel guys (whom I think of as Ford guys
) will swear by enamels, and indeed there are many benefits that are not easy to argue against. But for me, enamels are difficult to clean up, require nastier thinners and plain smells bad. I have some old Testor's enamel paints that have completely separated which I haven't been able to remix, and some equally old Tamiya acrylic that I use like it was new.
I switched entirely to Tamiya acrylics when I came back to the fold. I prefer the soap and water clean up, and I (and my wife and kids) find that the smell is preferable to enamels. They still think the paint is smelly, just less so. I can attest to the ease of cleaning, the other day I dripped some Tamiya on my white shorts and washed it right out using normal soap and water. I would have hated to try that with enamel!
I tried using different brands, in my case Model Master Acryl and Tamiya, but I never attempted to mix them together. I have used both kinds of paints on the same model with no problem. I dropped the MM Acryl after having some difficulty cleaning up my AB. I've decided to use Tamiya exclusively for no other reason than uniformity. I built a paint shelf that works with the Tamiya bottle, and MM Acryl are too tall. Gunze Sangyo paints use the same kind of bottle, but are not available at my LHS. MM Acryl brushes easier than Tamiya. Well, what I mean is you can go to a second coat or change of color faster. Tamiya tends to "roll up" when it hasn't had a chance to cure. I thin my brush paint a little thicker than I do for airbrushing which helps.
Acrylics seem to require additional consideration when preparing the surface. As the paint isn't as aggressive as enamels, you must insure a very clean surface, perhaps even so far as to require a primer coat, though I typically don't use one. Acrylics tend to have a longer cure time, depending on your humidity. My building and painting habits are such that I can let the paint cure for at least a couple of days before masking and painting a second color, and have on occasion gone for longer than a week between coats. I have yet to experience any lifting, though that may be luck more than skill!
You can use both enamels and acrylics, but make darn sure that the acrylic is fully cured before painting enamels over top.
Polly Scale (is that the same as Polly S?) seems to be marketed directly at the model railroad enthusiast, though I have heard their paints are excellent. You might have trouble matching colors as aircraft and armor tend to be painted differently than the average box car! If I ever build a model that requires me to paint a large solid of white (say the Avro Arrow!) I would likely use Polly Scale Reefer White, as it comes recommended to me. Tamiya light colors require a primer coat and multiple applications, but that is not unexpected.