Fred is essentially correct about the relative toxicity of acrylics vs. enamels and their thinners, and that acrylics should not be regarded as essentially nontoxic. They do contain various organic chemicals, including solvents, but their organic volatile component is generally quite low. Some of them use various alcohols as primary solvents or as cosolvents for water or other cosolvents.
Overall, their toxicity can be regarded as low, provided they are used properly. The same can be said of their primary reducing solvents, (thinners for spraying) which are usually either water or an alcohol. Cleaning solvents are usually detergent or soap and water, Simple Green (a commercial surfactant-soap), Windex (or similar ammoniated cleaner), or alcohol. Common alcohols are flammable, and you can get drunk on the vapors.
I would never rely on a spraybooth that merely filtered the air and returned it to the room, even for acrylics. For enamels and lacquers, they are "right out" as far as I'm concerned. Vented to the outside is the one, true, right, and only way, IMHO.