Mr Surfacer is essentially just a thick lacquer based paint. Typically, you apply it with a brush over fine seams, scratches, ejector pin marks and sink marks. When dry it sands fairly easily. It can also be stippled on with a brush to simulate rough-cast or rolled armour. Clean up your brush using lacquer thinner.
Mr Mark Setter is roughly analagous to MicroSet and is applied to the surface to be decalled before the decal is applied. My understanding is that unlike MicroSet, it has some adhesive properties. I haven't used Mr Mark Setter yet, but am planning to get some to try.
I have used Mr Mark Softer and it's similar to MicroSol - a softening agent. It's quite strong so use it sparingly. I'd suggest testing on a spare decal when you use it on any given build, because results may vary. I've had some which are totally unresponsive and others which look like they're going to melt and run off. I've also read accounts of it bleaching underlying paint and/or the decals themselves.
Both varieties of setting solutions have applicator brushes in the bottle caps.