Hello!
Basically, if you are able to make the two parts fit tight without glue, take CA. It holds best, when the glue layer is very thin. If the fit is loose, it might be better to use epoxy, this works better than CA if the glue layer is thick.
Josh - as for your question, I said "not so easy" in reference to replacing specialized plastic glues with a single component solvent. But if you get an idea what to look for and, roughly, how to mix it, you really can cut cost on plastic glue (this isn't really much), but also you can get around without mail-ordering such glue or without a hobby shop around - you just go to the hardware store...
Problem with pure MEK or acetone is they don't really solve all plastics well, but worst thing about them is that they evaporate too fast to let you work on anything but the smallest parts. The only way is to put the parts together and let the solvent wick into the seam - but this is not always possible/practical/desirable. But glues with some acetate mixed in solve plastics a lot better and linger a lot longer, allowing you to apply the glue to both surfaces and join the parts afterwards.
I hope that explains it - thanks for reading and have a nice day
Paweł