Depends on the subject. Historic representation or Artistic? I do both. I use artist acrylics, oils, and pastels over enamels because these are easier to mix and blend. I think I own one bottle of Model Masters.
Right now, I have the Thermopoylee in a metallic green/gold/blue blend. The masts are all black so the sails stand out more. The real ship didn't look that way, but my client does't want scale colors, they don't match the colors of her furniture. I have a lot of fun not painting to scale.