I have had to go exclusively with Acrylics,,,,,,,after over 40 years with enamels.
I do have a couple of "cheats" left around the house yet, though,,,,,,,I kept the Alclad primer as a back up in case I don't like my Acrylic primers, and I still have some lacquer thinner around in case I hit a tough cleaning job someday.
I also still have some of the putties and surfacers around, I haven't found a good substitute yet. It is hard to find a putty that tops the Tamiya and Mr Putty and Bondo Glazing putty, or a surfacer better than Mr Surfacer.
The number one difference between using an Acrylic and using an Enamel, as long as the smell is not an issue, is the outlook in how you use them. For Acrylics, we have to work at extending the working time, and preventing tip dry in the airbrush,,,,,for Enamels, we use things like Japan Drier to speed up the drying time.
But, once you master either one,,,,,,,you can get the same results with them. I know which models were painted back in my Enamel days, and which are from my current Acrylic days,,,,,and I am the only one that can tell. In ten years, unless I remember the exact time I built the model, I won't know which was the last of the Enamel models and which was done this year. For that matter, over on the "really old builds shelf", I can't tell the Enamel models from the "real" Dio-sol Floquil painted models.
The main importance is to start off with the manufacturer's recommendations, and then to follow any of the hot tips you read on the forums afterwards. That way, you have a level to fall back on,,,,,,,,,which you won't have if you buy a paint and dive in with 5 hot tips for using it on your first attempt. If it doesn't work, you won't know what went wrong, and it will be hard for people to give you any help.
Rex